Tel: +44 (0) 1442 402399

 

Mob: +44 (0) 7966 783845

 

Email: info@chromsolutions.co.uk

Training course 1 – Sample preparation for bio analysis

Is designed to suit the analytical chemist working in the DMPK /ADME areas of drug analysis.  The first part of this course deals with the fundamentals and benefits of sample preparation using Solid Phase Extraction (SPE). The course then moves on to deal with more specific issues and applications as they apply to bio analytical samples.

 

Core Topics

•  An introduction to the language technology and benefits of using SPE.

• Optimising non-polar extractions, applications method developments and troubleshooting.

• Optimising polar extractions, applications method development and troubleshooting.

• Optimising ion exchange extractions, applications method development and trouble shooting.

 

 

Sample preparation for bioanalysis

• Optimisation and development of methods for bioanalysis

• Understanding and application of mixed mode sorbents.

• Sample  preparation strategies using 96 well plates

• Pros and cons of protein precipitation.

• Is faster necessarily more efficient.

• On line and automated methods.

• Emerging technologies and new applications

 

Please contact us to book at

ChromSolutions Ltd

92 Hobletts Road Hemel Hempstead HP2 5LP UK

 

Training course 2 – Strategies for Synthesis chemistry and Purification.

The format of this course after the core material has been delivered deals with the isolations and purification of chemical compounds from synthesis chemistry reaction mixtures. The course then examines is some detail the theory and practice of flash chromatography

Click here for the full course details

 

• An introduction to the language technology and benefits of using SPE.

• Optimising non-polar extractions, applications method developments and troubleshooting.

• Optimising polar extractions, applications method development and troubleshooting.

• Optimising ion exchange extractions, applications method development and trouble shooting.

 

1. Liquid / liquid extractions on solid supports

2. Use of larger volume SPE columns for the clean-up synthesis chemistry mixtures.

3. 96 well plate application and automation issues.

4. Principles & techniques in flash chromatography.

 

Please contact us to book at

ChromSolutions Ltd

92 Hobletts Road Hemel Hempstead HP2 5LP UK

 

 

One Day Solid Phase Extraction Training Course

Pharmaceutical Analysis 1

 

Solid Phase Extraction will be Wednesday the 3rd of June 2010 for Bioanalytical applications

 

Core Material

 

• The basics of SPE – A Gentle Introduction

• Understanding the behaviour of bonded phase silica’s

• Reverse Phase (Non Polar) SPE method development and optimisation.

• Normal Phase (Polar) SPE method development and optimisation.

• Ion Exchange Principles Practice and Techniques.Method Development and optimisation.

 

 

Applications for Bioanalysis

 

• Handling Biological samples specific sorbents for general screening.

• High Throughput applications using 96 well plates and linking up with LC/MS

• Extracting Drugs and Metabolites from Solid Samples.

• Clean up strategies for protein digests prior to MALDI TOF MS analysis.

• Automation strategies and applications of New and emerging SPE Technologies including membrane based phases.

• Summary of key issues in methods development

 

One Day Solid Phase Extraction Training Course

Pharmaceutical Analysis 2 Core Material

 

• The basics of SPE – A Gentle Introduction

• Understanding the behaviour of bonded phase silica’s

• Reverse Phase (Non Polar) SPE method development and optimisation.

• Normal Phase (Polar) SPE method development and optimisation.

• Ion Exchange Principles Practice and Techniques. Method Development and optimisation.

 

Applications For Synthesis Chemistry

 

• Liquid / Liquid extractions on Solid Supports

• Use of large volume SPE columns for clean up of synthesis mixtures.

• 96 well plate application and automation issues.

• Principles and techniques in flash chromatography.

 

Environmental Course 1 - Extraction and analysis of environmental samples.

 

ChromSolutions is pleased to offer this course which is especially useful  for analytical chemists charged with having to extract and analyse compounds from water food and soil. These types of samples tend to present the biggest challenge because of the nature of the sample matrix. The course takes an  in depth look at extraction strategies for a variety of priority pollutants in water samples and deals with issues of large sample volume and trace enrichment.

For more details about this course please click here

 

Core Topics

• An introduction to the language technology and benefits of using SPE.

• Optimising non-polar extractions, applications method developments and troubleshooting.

• Optimising polar extractions, applications method development and troubleshooting.

• Optimising ion exchange extractions, applications method development and trouble shooting.

 

Extraction and analysis of environmental samples.

• Extraction of pesticides and priority pollutants from food water and soil.

 

• Advanced applications of SPE so discussion of mixed mode, Molecular imprinted polymers and the SPE of metals.

 

• Demonstration of SPE using coloured food dyes in the lab – This is optional but very useful and visual to demonstrate the power of this technique.

 

• Round table discussion so an opportunity to discuss the above and it how may apply to your specific compounds and sample types.

 

Practical Gas Chromatography (GC)

 

This course will enable the attendee to gain more useful insight into the application of GC in chemical analysis. The course looks at the theory and practice of the technique with respect to injection technique, selective detectors including mass spectrometers and column choice. The course also discusses the customisation of GC for bespoke applications

 

For course details please click here:

 

Gas chromatography Part 1

• GC History

• What is a GC

• GC columns choice and applications

• GC Injectors / Injection technique choice applications and troubleshooting

Gas Chromatography Part 2

• GC detectors FID,ECD, TSD FPD

• The Ultimate GC detector – MS

• Auto samplers

• Headspace applications theory and practice